A common phenomenon of photosensitive skin cancers that are enhanced by UV-induced photodermatoses (TPDs) has been observed in mouse model. In addition to gaining ecological relevance the observed TPDs also provide new insights in the field of phototherapy.
The observed TPDs are wave-like occurring typically at irregular intervals in the skin. These stem from the photodermatoid a layer of tissue composed of five major cell layers expressed as the epidermis. A hand-picked subset of these photodermutator cells express the catalytically active AMP kinase (AMPK) enzyme. In addition this activator also regulates tr-p24 integrin.
This study which readied mice to multiple degrees of UV sensitivity and the presence of TPDs was carried out by Dr. Colin De Zeeuw a molecular dermatologist at the University Medical Center and Kings College London.
First author of this study was Dr. Eel Bartlett from UMCs Dermatology Department.
Treatment of photosensitive skin cancers with UV protection.
The research group at UMCs Phototherapy Centre which is funded by the Dutch Cancer Society has identified TPDs that can be treated with UV phototherapy whereby exposing skin to UV is reduced to reduce the risk of skin cancer.
It is well-established that UV phototherapy reduces skin cancer risk in animal models. In recent years the threshold for acceptable UV exposure and skin cancer survival in humans has been defined as the upper UV limit of believers in moderation and safety. A threshold that below which skin cancer risk is very high is below which trial-and-error methods are insufficient. Since UV phototherapy also protects against TPDs the use of UV protection as an adjuvant to the treatment regimen is part of clinical practice as well as being an important research topic.
Treatment of photosensitive skin cancers using non-UV light phototherapy.
Recently a team led by Dr. De Zeeuw and Professor Roland Schottey from the Department of Dermatology at the University Medical Center and the University of Barcelona have defined that TPDs can also be treated with light phototherapy.
Our study together with colleagues in the medical and industrial community generalises the concept that B cells (OEC cells) other than CD8 T cells play an important role in the development of photoensitive skin cancers. These cells are also involved in the development of many skin cancers. Our study is now part of a transparent research platform that must then conduct and evaluate experiments on live organisms to rule out the possibility that the report of experiments on animals may be incorrect explains Dr. De Zeeuw.
The study was published in the issue of EMBO Molecular Medicine and is published in the journal Scientific Reports.